PAK4-B9D1 Fusion FISH Probe
The PAK4-B9D1 Fusion FISH Probe is used to confirm a fusion of the PAK4 and B9D1 genes. The fusion of the PAK4 and B9D1 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PAK4-B9D1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-RERE | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-REOR | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-REGO | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-REGR | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-REAQ | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-ORRE | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-OROR | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-ORGO | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-GORE | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-GOOR | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-GOGO | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-GOGR | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-GRRE | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-GROR | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-GRGO | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-GRGR | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-AQRE | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-AQOR | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-AQGO | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-AQGR | 20 (40 μL) | 200 μL |
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| PAK4-B9D1-20-AQAQ | 20 (40 μL) | 200 μL |
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PAK4 Gene Summary
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: P21 (RAC1) Activated Kinase 4
Chromosome: CHR19: 39616419 -39670046
Locus: 19q13.2
B9D1 Gene Summary
This gene encodes a B9 domain-containing protein, one of several that are involved in ciliogenesis. Alterations in expression of this gene have been found in a family with Meckel syndrome. Meckel syndrome has been associated with at least six different genes. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Mar 2016]
Gene Name: B9 Domain Containing 1
Chromosome: CHR17: 19240866 -19281495
Locus: 17p11.2
Gene Diseases
The PAK4 B9D1 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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