PAK3-SH2D1A Fusion FISH Probe
The PAK3-SH2D1A Fusion FISH Probe is used to confirm a fusion of the PAK3 and SH2D1A genes. The fusion of the PAK3 and SH2D1A genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PAK3-SH2D1A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PAK3-SH2D1A-20-AQAQ | 20 (40 μL) | 200 μL |
|
SH2D1A Gene Summary
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: SH2 Domain Containing 1A
Chromosome: CHRX: 123480131 -123507010
Locus: Xq25
PAK3 Gene Summary
The protein encoded by this gene is a serine-threonine kinase and forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of a non-syndromic form of X-linked intellectual disability. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2017]
Gene Name: P21 (RAC1) Activated Kinase 3
Chromosome: CHRX: 110187512 -110464173
Locus: Xq23
Gene Diseases
The PAK3 SH2D1A Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|