PAK1-THRSP Fusion FISH Probe
The PAK1-THRSP Fusion FISH Probe is used to confirm a fusion of the PAK1 and THRSP genes. The fusion of the PAK1 and THRSP genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PAK1-THRSP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-RERE | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-REOR | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-REGO | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-REGR | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-REAQ | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-ORRE | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-OROR | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-ORGO | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-ORAQ | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-GORE | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-GOOR | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-GOGO | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-GOGR | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-GOAQ | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-GRRE | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-GROR | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-GRGO | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-GRGR | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-GRAQ | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-AQRE | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-AQOR | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-AQGO | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-AQGR | 20 (40 μL) | 200 μL |
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| PAK1-THRSP-20-AQAQ | 20 (40 μL) | 200 μL |
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PAK1 Gene Summary
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Gene Name: P21 (RAC1) Activated Kinase 1
Chromosome: CHR11: 77033059 -77185108
Locus: 11q13.5-q14.1
THRSP Gene Summary
The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]
Gene Name: Thyroid Hormone Responsive
Chromosome: CHR11: 77774906 -77779403
Locus: 11q14.1
Gene Diseases
The PAK1 THRSP Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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