PAK1-PDGFD Fusion FISH Probe
The PAK1-PDGFD Fusion FISH Probe is used to confirm a fusion of the PAK1 and PDGFD genes. The fusion of the PAK1 and PDGFD genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| PAK1-PDGFD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-RERE | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-REOR | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-REGO | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-REGR | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-OROR | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-GORE | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-GROR | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| PAK1-PDGFD-20-AQAQ | 20 (40 μL) | 200 μL |
|
PAK1 Gene Summary
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Gene Name: P21 (RAC1) Activated Kinase 1
Chromosome: CHR11: 77033059 -77185108
Locus: 11q13.5-q14.1
PDGFD Gene Summary
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Platelet Derived Growth Factor D
Chromosome: CHR11: 103777913 -104035027
Locus: 11q22.3
Gene Diseases
The PAK1 PDGFD Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|