PAK1-NARS2 Fusion FISH Probe
The PAK1-NARS2 Fusion FISH Probe is used to confirm a fusion of the PAK1 and NARS2 genes. The fusion of the PAK1 and NARS2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PAK1-NARS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-RERE | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-REOR | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-REGO | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-REGR | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-REAQ | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-ORRE | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-OROR | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-ORGO | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-GORE | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-GOOR | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-GOGO | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-GOGR | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-GRRE | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-GROR | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-GRGO | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-GRGR | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-AQRE | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-AQOR | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-AQGO | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-AQGR | 20 (40 μL) | 200 μL |
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| PAK1-NARS2-20-AQAQ | 20 (40 μL) | 200 μL |
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PAK1 Gene Summary
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Gene Name: P21 (RAC1) Activated Kinase 1
Chromosome: CHR11: 77033059 -77185108
Locus: 11q13.5-q14.1
NARS2 Gene Summary
This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of asparagine to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 24 (COXPD24). [provided by RefSeq, Mar 2015]
Gene Name: Asparaginyl-tRNA Synthetase 2, Mitochondrial
Chromosome: CHR11: 78147006 -78285909
Locus: 11q14.1
Gene Diseases
The PAK1 NARS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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