PAK1-ERG Fusion FISH Probe
The PAK1-ERG Fusion FISH Probe is used to confirm a fusion of the PAK1 and ERG genes. The fusion of the PAK1 and ERG genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PAK1-ERG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-RERE | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-REOR | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-REGO | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-REGR | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-REAQ | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-ORRE | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-OROR | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-ORGO | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-ORAQ | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-GORE | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-GOOR | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-GOGO | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-GOGR | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-GOAQ | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-GRRE | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-GROR | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-GRGO | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-GRGR | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-GRAQ | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-AQRE | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-AQOR | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-AQGO | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-AQGR | 20 (40 μL) | 200 μL |
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| PAK1-ERG-20-AQAQ | 20 (40 μL) | 200 μL |
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ERG Gene Summary
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
Gene Name: ERG, ETS Transcription Factor
Chromosome: CHR21: 39739182 -40033618
Locus: 21q22.2
PAK1 Gene Summary
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Gene Name: P21 (RAC1) Activated Kinase 1
Chromosome: CHR11: 77033059 -77185108
Locus: 11q13.5-q14.1
Gene Diseases
The PAK1 ERG Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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