PAIP1-DAB2 Fusion FISH Probe
The PAIP1-DAB2 Fusion FISH Probe is used to confirm a fusion of the PAIP1 and DAB2 genes. The fusion of the PAIP1 and DAB2 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PAIP1-DAB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-RERE | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-REOR | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-REGO | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-REGR | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-REAQ | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-ORRE | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-OROR | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-ORGO | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-GORE | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-GOOR | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-GOGO | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-GOGR | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-GRRE | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-GROR | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-GRGO | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-GRGR | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-AQRE | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-AQOR | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-AQGO | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-AQGR | 20 (40 μL) | 200 μL |
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| PAIP1-DAB2-20-AQAQ | 20 (40 μL) | 200 μL |
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DAB2 Gene Summary
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: DAB2, Clathrin Adaptor Protein
Chromosome: CHR5: 39371779 -39425335
Locus: 5p13.1
PAIP1 Gene Summary
The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Poly(A) Binding Protein Interacting Protein 1
Chromosome: CHR5: 43526369 -43557521
Locus: 5p12
Gene Diseases
The PAIP1 DAB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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