PAH-METAP2 Fusion FISH Probe
The PAH-METAP2 Fusion FISH Probe is used to confirm a fusion of the PAH and METAP2 genes. The fusion of the PAH and METAP2 genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PAH-METAP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-RERE | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-REOR | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-REGO | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-REGR | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-REAQ | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-ORRE | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-OROR | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-ORGO | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-GORE | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-GOOR | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-GOGO | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-GOGR | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-GRRE | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-GROR | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-GRGO | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-GRGR | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-AQRE | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-AQOR | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-AQGO | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-AQGR | 20 (40 μL) | 200 μL |
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| PAH-METAP2-20-AQAQ | 20 (40 μL) | 200 μL |
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PAH Gene Summary
This gene encodes a member of the biopterin-dependent aromatic amino acid hydroxylase protein family. The encoded phenylalanine hydroxylase enzyme hydroxylates phenylalanine to tyrosine and is the rate-limiting step in phenylalanine catabolism. Deficiency of this enzyme activity results in the autosomal recessive disorder phenylketonuria. [provided by RefSeq, Aug 2017]
Gene Name: Phenylalanine Hydroxylase
Chromosome: CHR12: 103232103 -103311381
Locus: 12q23.2
METAP2 Gene Summary
The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Gene Name: Methionyl Aminopeptidase 2
Chromosome: CHR12: 95867821 -95909613
Locus: 12q22
Gene Diseases
The PAH METAP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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