PAFAH1B2-MRPL2 Fusion FISH Probe
The PAFAH1B2-MRPL2 Fusion FISH Probe is used to confirm a fusion of the PAFAH1B2 and MRPL2 genes. The fusion of the PAFAH1B2 and MRPL2 genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PAFAH1B2-MRPL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-RERE | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-REOR | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-REGO | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-REGR | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-REAQ | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-ORRE | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-OROR | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-ORGO | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-GORE | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-GOOR | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-GOGO | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-GOGR | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-GRRE | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-GROR | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-GRGO | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-GRGR | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-AQRE | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-AQOR | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-AQGO | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-AQGR | 20 (40 μL) | 200 μL |
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| PAFAH1B2-MRPL2-20-AQAQ | 20 (40 μL) | 200 μL |
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PAFAH1B2 Gene Summary
Platelet-activating factor acetylhydrolase (PAFAH) inactivates platelet-activating factor (PAF) into acetate and LYSO-PAF. This gene encodes the beta subunit of PAFAH, the other subunits are alpha and gamma. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2014]
Gene Name: Platelet Activating Factor Acetylhydrolase 1b Catalytic Subunit 2
Chromosome: CHR11: 117014999 -117047592
Locus: 11q23.3
MRPL2 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Gene Name: Mitochondrial Ribosomal Protein L2
Chromosome: CHR6: 43021766 -43027242
Locus: 6p21.1
Gene Diseases
The PAFAH1B2 MRPL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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