PAFAH1B1-ABR Fusion FISH Probe
The PAFAH1B1-ABR Fusion FISH Probe is used to confirm a fusion of the PAFAH1B1 and ABR genes. The fusion of the PAFAH1B1 and ABR genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PAFAH1B1-ABR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-RERE | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-REOR | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-REGO | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-REGR | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-REAQ | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-ORRE | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-OROR | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-ORGO | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-ORAQ | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-GORE | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-GOOR | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-GOGO | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-GOGR | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-GOAQ | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-GRRE | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-GROR | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-GRGO | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-GRGR | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-GRAQ | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-AQRE | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-AQOR | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-AQGO | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-AQGR | 20 (40 μL) | 200 μL |
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| PAFAH1B1-ABR-20-AQAQ | 20 (40 μL) | 200 μL |
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ABR Gene Summary
This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]
Gene Name: Active BCR-related
Chromosome: CHR17: 906758 -1090616
Locus: 17p13.3
PAFAH1B1 Gene Summary
This locus was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller-Dieker lissencephaly syndrome. This gene encodes the non-catalytic alpha subunit of the intracellular Ib isoform of platelet-activating factor acteylhydrolase, a heterotrimeric enzyme that specifically catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist: one composed of multiple subunits, the other, a single subunit. In addition, a single-subunit isoform of this enzyme is found in serum. [provided by RefSeq, Apr 2009]
Gene Name: Platelet Activating Factor Acetylhydrolase 1b Regulatory Subunit 1
Chromosome: CHR17: 2496922 -2588909
Locus: 17p13.3
Gene Diseases
The PAFAH1B1 ABR Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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