PAEP-FAR1 Fusion FISH Probe
The PAEP-FAR1 Fusion FISH Probe is used to confirm a fusion of the PAEP and FAR1 genes. The fusion of the PAEP and FAR1 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PAEP-FAR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-RERE | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-REOR | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-REGO | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-REGR | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-REAQ | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-ORRE | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-OROR | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-ORGO | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-GORE | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-GOOR | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-GOGO | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-GOGR | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-GRRE | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-GROR | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-GRGO | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-GRGR | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-AQRE | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-AQOR | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-AQGO | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-AQGR | 20 (40 μL) | 200 μL |
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| PAEP-FAR1-20-AQAQ | 20 (40 μL) | 200 μL |
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PAEP Gene Summary
This gene is a member of the kernel lipocalin superfamily whose members share relatively low sequence similarity but have highly conserved exon/intron structure and three-dimensional protein folding. Most lipocalins are clustered on the long arm of chromosome 9. The encoded glycoprotein has been previously referred to as pregnancy-associated endometrial alpha-2-globulin, placental protein 14, and glycodelin, but has been officially named progestagen-associated endometrial protein. Three distinct forms, with identical protein backbones but different glycosylation profiles, are found in amniotic fluid, follicular fluid and seminal plasma of the reproductive system. These glycoproteins have distinct and essential roles in regulating a uterine environment suitable for pregnancy and in the timing and occurrence of the appropriate sequence of events in the fertilization process. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Gene Name: Progestagen Associated Endometrial Protein
Chromosome: CHR9: 138453603 -138458622
Locus: 9q34.3
FAR1 Gene Summary
The protein encoded by this gene is required for the reduction of fatty acids to fatty alcohols, a process that is required for the synthesis of monoesters and ether lipids. NADPH is required as a cofactor in this reaction, and 16-18 carbon saturated and unsaturated fatty acids are the preferred substrate. This is a peroxisomal membrane protein, and studies suggest that the N-terminus contains a large catalytic domain located on the outside of the peroxisome, while the C-terminus is exposed to the matrix of the peroxisome. Studies indicate that the regulation of this protein is dependent on plasmalogen levels. Mutations in this gene have been associated with individuals affected by severe intellectual disability, early-onset epilepsy, microcephaly, congenital cataracts, growth retardation, and spasticity (PMID: 25439727). A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jan 2015]
Gene Name: Fatty Acyl-CoA Reductase 1
Chromosome: CHR11: 13690205 -13753893
Locus: 11p15.3
Gene Diseases
The PAEP FAR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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