PACS1-PPP2R5B Fusion FISH Probe
The PACS1-PPP2R5B Fusion FISH Probe is used to confirm a fusion of the PACS1 and PPP2R5B genes. The fusion of the PACS1 and PPP2R5B genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PACS1-PPP2R5B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-RERE | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-REOR | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-REGO | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-REGR | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-REAQ | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-ORRE | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-OROR | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-ORGO | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-ORAQ | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-GORE | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-GOOR | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-GOGO | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-GOGR | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-GOAQ | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-GRRE | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-GROR | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-GRGO | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-GRGR | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-GRAQ | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-AQRE | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-AQOR | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-AQGO | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-AQGR | 20 (40 μL) | 200 μL |
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| PACS1-PPP2R5B-20-AQAQ | 20 (40 μL) | 200 μL |
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PPP2R5B Gene Summary
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]
Gene Name: Protein Phosphatase 2 Regulatory Subunit B'beta
Chromosome: CHR11: 64692142 -64701950
Locus: 11q13.1
PACS1 Gene Summary
This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008]
Gene Name: Phosphofurin Acidic Cluster Sorting Protein 1
Chromosome: CHR11: 65837823 -66012213
Locus: 11q13.1-q13.2
Gene Diseases
The PACS1 PPP2R5B Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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