PABPC4-MACF1 Fusion FISH Probe
The PABPC4-MACF1 Fusion FISH Probe is used to confirm a fusion of the PABPC4 and MACF1 genes. The fusion of the PABPC4 and MACF1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| PABPC4-MACF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-RERE | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-REOR | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-REGO | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-REGR | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-REAQ | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-ORRE | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-OROR | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-ORGO | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-GORE | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-GOOR | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-GOGO | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-GOGR | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-GRRE | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-GROR | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-GRGO | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-GRGR | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-AQRE | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-AQOR | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-AQGO | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-AQGR | 20 (40 μL) | 200 μL |
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| PABPC4-MACF1-20-AQAQ | 20 (40 μL) | 200 μL |
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PABPC4 Gene Summary
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Gene Name: Poly(A) Binding Protein Cytoplasmic 4
Chromosome: CHR1: 40026484 -40042521
Locus: 1p34.3
MACF1 Gene Summary
This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]
Gene Name: Microtubule-actin Crosslinking Factor 1
Chromosome: CHR1: 39547088 -39952810
Locus: 1p34.3
Gene Diseases
The PABPC4 MACF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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