P4HB-ZFP91 Fusion FISH Probe
The P4HB-ZFP91 Fusion FISH Probe is used to confirm a fusion of the P4HB and ZFP91 genes. The fusion of the P4HB and ZFP91 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| P4HB-ZFP91-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-RERE | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-REOR | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-REGO | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-REGR | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-REAQ | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-ORRE | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-OROR | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-ORGO | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-ORAQ | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-GORE | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-GOOR | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-GOGO | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-GOGR | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-GOAQ | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-GRRE | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-GROR | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-GRGO | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-GRGR | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-GRAQ | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-AQRE | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-AQOR | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-AQGO | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-AQGR | 20 (40 μL) | 200 μL |
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| P4HB-ZFP91-20-AQAQ | 20 (40 μL) | 200 μL |
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P4HB Gene Summary
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
Gene Name: Prolyl 4-hydroxylase Subunit Beta
Chromosome: CHR17: 79801033 -79818544
Locus: 17q25.3
ZFP91 Gene Summary
The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]
Gene Name: ZFP91 Zinc Finger Protein
Chromosome: CHR11: 58346586 -58389023
Locus: 11q12.1
Gene Diseases
The P4HB ZFP91 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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