P4HB-TPT1 Fusion FISH Probe
The P4HB-TPT1 Fusion FISH Probe is used to confirm a fusion of the P4HB and TPT1 genes. The fusion of the P4HB and TPT1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| P4HB-TPT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-RERE | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-REOR | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-REGO | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-REGR | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-REAQ | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-ORRE | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-OROR | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-ORGO | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-ORAQ | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-GORE | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-GOOR | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-GOGO | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-GOGR | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-GOAQ | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-GRRE | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-GROR | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-GRGO | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-GRGR | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-GRAQ | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-AQRE | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-AQOR | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-AQGO | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-AQGR | 20 (40 μL) | 200 μL |
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| P4HB-TPT1-20-AQAQ | 20 (40 μL) | 200 μL |
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P4HB Gene Summary
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
Gene Name: Prolyl 4-hydroxylase Subunit Beta
Chromosome: CHR17: 79801033 -79818544
Locus: 17q25.3
TPT1 Gene Summary
This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Gene Name: Tumor Protein, Translationally-controlled 1
Chromosome: CHR13: 45911303 -45915297
Locus: 13q14.13
Gene Diseases
The P4HB TPT1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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