P4HB-SEC63 Fusion FISH Probe
The P4HB-SEC63 Fusion FISH Probe is used to confirm a fusion of the P4HB and SEC63 genes. The fusion of the P4HB and SEC63 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| P4HB-SEC63-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-RERE | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-REOR | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-REGO | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-REGR | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-REAQ | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-ORRE | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-OROR | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-ORGO | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-ORAQ | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-GORE | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-GOOR | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-GOGO | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-GOGR | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-GOAQ | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-GRRE | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-GROR | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-GRGO | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-GRGR | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-GRAQ | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-AQRE | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-AQOR | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-AQGO | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-AQGR | 20 (40 μL) | 200 μL |
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| P4HB-SEC63-20-AQAQ | 20 (40 μL) | 200 μL |
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P4HB Gene Summary
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
Gene Name: Prolyl 4-hydroxylase Subunit Beta
Chromosome: CHR17: 79801033 -79818544
Locus: 17q25.3
SEC63 Gene Summary
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Name: SEC63 Homolog, Protein Translocation Regulator
Chromosome: CHR6: 108188959 -108279482
Locus: 6q21
Gene Diseases
The P4HB SEC63 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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