P4HB-PLAT Fusion FISH Probe
The P4HB-PLAT Fusion FISH Probe is used to confirm a fusion of the P4HB and PLAT genes. The fusion of the P4HB and PLAT genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| P4HB-PLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-RERE | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-REOR | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-REGO | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-REGR | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-REAQ | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-ORRE | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-OROR | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-ORGO | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-GORE | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-GOOR | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-GOGO | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-GOGR | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-GRRE | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-GROR | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-GRGO | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-GRGR | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-AQRE | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-AQOR | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-AQGO | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-AQGR | 20 (40 μL) | 200 μL |
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| P4HB-PLAT-20-AQAQ | 20 (40 μL) | 200 μL |
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P4HB Gene Summary
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
Gene Name: Prolyl 4-hydroxylase Subunit Beta
Chromosome: CHR17: 79801033 -79818544
Locus: 17q25.3
PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
Gene Diseases
The P4HB PLAT Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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