P4HB-NDUFV1 Fusion FISH Probe
The P4HB-NDUFV1 Fusion FISH Probe is used to confirm a fusion of the P4HB and NDUFV1 genes. The fusion of the P4HB and NDUFV1 genes has been associated with Prostate Adenocarcinoma, and Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| P4HB-NDUFV1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-RERE | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-REOR | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-REGO | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-REGR | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-REAQ | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-ORRE | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-OROR | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-ORGO | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-ORAQ | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-GORE | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-GOOR | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-GOGO | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-GOGR | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-GOAQ | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-GRRE | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-GROR | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-GRGO | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-GRGR | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-GRAQ | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-AQRE | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-AQOR | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-AQGO | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-AQGR | 20 (40 μL) | 200 μL |
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| P4HB-NDUFV1-20-AQAQ | 20 (40 μL) | 200 μL |
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NDUFV1 Gene Summary
The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Gene Name: NADH:ubiquinone Oxidoreductase Core Subunit V1
Chromosome: CHR11: 67374322 -67380012
Locus: 11q13.2
P4HB Gene Summary
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
Gene Name: Prolyl 4-hydroxylase Subunit Beta
Chromosome: CHR17: 79801033 -79818544
Locus: 17q25.3
Gene Diseases
The P4HB NDUFV1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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