P4HB-MYO6 Fusion FISH Probe
The P4HB-MYO6 Fusion FISH Probe is used to confirm a fusion of the P4HB and MYO6 genes. The fusion of the P4HB and MYO6 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| P4HB-MYO6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-RERE | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-REOR | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-REGO | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-REGR | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-REAQ | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-ORRE | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-OROR | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-ORGO | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-ORAQ | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-GORE | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-GOOR | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-GOGO | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-GOGR | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-GOAQ | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-GRRE | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-GROR | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-GRGO | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-GRGR | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-GRAQ | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-AQRE | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-AQOR | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-AQGO | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-AQGR | 20 (40 μL) | 200 μL |
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| P4HB-MYO6-20-AQAQ | 20 (40 μL) | 200 μL |
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MYO6 Gene Summary
This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Gene Name: Myosin VI
Chromosome: CHR6: 76458908 -76629254
Locus: 6q14.1
P4HB Gene Summary
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
Gene Name: Prolyl 4-hydroxylase Subunit Beta
Chromosome: CHR17: 79801033 -79818544
Locus: 17q25.3
Gene Diseases
The P4HB MYO6 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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