P4HB-C7 Fusion FISH Probe
The P4HB-C7 Fusion FISH Probe is used to confirm a fusion of the P4HB and C7 genes. The fusion of the P4HB and C7 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| P4HB-C7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-RERE | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-REOR | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-REGO | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-REGR | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-REAQ | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-ORRE | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-OROR | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-ORGO | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-ORAQ | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-GORE | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-GOOR | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-GOGO | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-GOGR | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-GOAQ | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-GRRE | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-GROR | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-GRGO | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-GRGR | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-GRAQ | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-AQRE | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-AQOR | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-AQGO | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-AQGR | 20 (40 μL) | 200 μL |
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| P4HB-C7-20-AQAQ | 20 (40 μL) | 200 μL |
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C7 Gene Summary
This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency. [provided by RefSeq, Nov 2016]
Gene Name: Complement C7
Chromosome: CHR5: 40909598 -40983042
Locus: 5p13.1
P4HB Gene Summary
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
Gene Name: Prolyl 4-hydroxylase Subunit Beta
Chromosome: CHR17: 79801033 -79818544
Locus: 17q25.3
Gene Diseases
The P4HB C7 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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