P2RY6-MRPS35 Fusion FISH Probe
The P2RY6-MRPS35 Fusion FISH Probe is used to confirm a fusion of the P2RY6 and MRPS35 genes. The fusion of the P2RY6 and MRPS35 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| P2RY6-MRPS35-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-RERE | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-REOR | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-REGO | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-REGR | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-REAQ | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-ORRE | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-OROR | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-ORGO | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-ORAQ | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-GORE | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-GOOR | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-GOGO | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-GOGR | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-GOAQ | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-GRRE | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-GROR | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-GRGO | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-GRGR | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-GRAQ | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-AQRE | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-AQOR | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-AQGO | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-AQGR | 20 (40 μL) | 200 μL |
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| P2RY6-MRPS35-20-AQAQ | 20 (40 μL) | 200 μL |
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P2RY6 Gene Summary
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]
Gene Name: Pyrimidinergic Receptor P2Y6
Chromosome: CHR11: 72975569 -73008850
Locus: 11q13.4
MRPS35 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010]
Gene Name: Mitochondrial Ribosomal Protein S35
Chromosome: CHR12: 27863705 -27909237
Locus: 12p11.22
Gene Diseases
The P2RY6 MRPS35 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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