OXCT1-GHR Fusion FISH Probe
The OXCT1-GHR Fusion FISH Probe is used to confirm a fusion of the OXCT1 and GHR genes. The fusion of the OXCT1 and GHR genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OXCT1-GHR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-RERE | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-REOR | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-REGO | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-REGR | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-REAQ | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-ORRE | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-OROR | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-ORGO | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-ORAQ | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-GORE | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-GOOR | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-GOGO | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-GOGR | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-GOAQ | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-GRRE | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-GROR | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-GRGO | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-GRGR | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-GRAQ | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-AQRE | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-AQOR | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-AQGO | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-AQGR | 20 (40 μL) | 200 μL |
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| OXCT1-GHR-20-AQAQ | 20 (40 μL) | 200 μL |
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GHR Gene Summary
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Gene Name: Growth Hormone Receptor
Chromosome: CHR5: 42423876 -42721980
Locus: 5p13.1-p12
OXCT1 Gene Summary
This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008]
Gene Name: 3-oxoacid CoA-transferase 1
Chromosome: CHR5: 41730166 -41870791
Locus: 5p13.1
Gene Diseases
The OXCT1 GHR Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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