OTUD5-GRIPAP1 Fusion FISH Probe
The OTUD5-GRIPAP1 Fusion FISH Probe is used to confirm a fusion of the OTUD5 and GRIPAP1 genes. The fusion of the OTUD5 and GRIPAP1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OTUD5-GRIPAP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-RERE | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-REOR | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-REGO | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-REGR | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-REAQ | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-ORRE | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-OROR | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-ORGO | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-GORE | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-GOOR | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-GOGO | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-GOGR | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-GRRE | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-GROR | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-GRGO | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-GRGR | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-AQRE | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-AQOR | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-AQGO | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-AQGR | 20 (40 μL) | 200 μL |
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| OTUD5-GRIPAP1-20-AQAQ | 20 (40 μL) | 200 μL |
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OTUD5 Gene Summary
This gene encodes a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and the encoded protein has been shown to suppress the type I interferon-dependent innate immune response by cleaving the polyubiquitin chain from an essential type I interferon adaptor protein. Cleavage results in disassociation of the adaptor protein from a downstream signaling complex and disruption of the type I interferon signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2008]
Gene Name: OTU Deubiquitinase 5
Chromosome: CHRX: 48779302 -48815648
Locus: Xp11.23
GRIPAP1 Gene Summary
This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by RefSeq, Aug 2013]
Gene Name: GRIP1 Associated Protein 1
Chromosome: CHRX: 48830133 -48858675
Locus: Xp11.23
Gene Diseases
The OTUD5 GRIPAP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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