OTUB1-COX8A Fusion FISH Probe
The OTUB1-COX8A Fusion FISH Probe is used to confirm a fusion of the OTUB1 and COX8A genes. The fusion of the OTUB1 and COX8A genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OTUB1-COX8A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-RERE | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-REOR | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-REGO | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-REGR | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-REAQ | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-ORRE | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-OROR | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-ORGO | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-ORAQ | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-GORE | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-GOOR | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-GOGO | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-GOGR | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-GOAQ | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-GRRE | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-GROR | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-GRGO | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-GRGR | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-GRAQ | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-AQRE | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-AQOR | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-AQGO | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-AQGR | 20 (40 μL) | 200 μL |
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| OTUB1-COX8A-20-AQAQ | 20 (40 μL) | 200 μL |
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COX8A Gene Summary
The protein encoded by this gene is the terminal enzyme of the respiratory chain, coupling the transfer of electrons from cytochrome c to molecular oxygen, with the concomitant production of a proton electrochemical gradient across the inner mitochondrial membrane. In addition to 3 mitochondrially encoded subunits, which perform the catalytic function, the eukaryotic enzyme contains nuclear-encoded smaller subunits, ranging in number from 4 in some organisms to 10 in mammals. It has been proposed that nuclear-encoded subunits may be involved in the modulation of the catalytic function. This gene encodes one of the nuclear-encoded subunits. [provided by RefSeq, Jul 2008]
Gene Name: Cytochrome C Oxidase Subunit 8A
Chromosome: CHR11: 63742078 -63744015
Locus: 11q13.1
OTUB1 Gene Summary
The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Name: OTU Deubiquitinase, Ubiquitin Aldehyde Binding 1
Chromosome: CHR11: 63753324 -63765892
Locus: 11q13.1
Gene Diseases
The OTUB1 COX8A Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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