OSTM1-SNX3 Fusion FISH Probe
The OSTM1-SNX3 Fusion FISH Probe is used to confirm a fusion of the OSTM1 and SNX3 genes. The fusion of the OSTM1 and SNX3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OSTM1-SNX3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-RERE | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-REOR | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-REGO | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-REGR | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-REAQ | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-ORRE | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-OROR | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-ORGO | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-ORAQ | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-GORE | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-GOOR | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-GOGO | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-GOGR | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-GOAQ | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-GRRE | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-GROR | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-GRGO | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-GRGR | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-GRAQ | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-AQRE | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-AQOR | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-AQGO | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-AQGR | 20 (40 μL) | 200 μL |
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| OSTM1-SNX3-20-AQAQ | 20 (40 μL) | 200 μL |
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SNX3 Gene Summary
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Gene Name: Sorting Nexin 3
Chromosome: CHR6: 108532716 -108582464
Locus: 6q21
OSTM1 Gene Summary
This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. [provided by RefSeq, Jul 2008]
Gene Name: Osteopetrosis Associated Transmembrane Protein 1
Chromosome: CHR6: 108362612 -108395941
Locus: 6q21
Gene Diseases
The OSTM1 SNX3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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