OSBPL8-SYT1 Fusion FISH Probe
The OSBPL8-SYT1 Fusion FISH Probe is used to confirm a fusion of the OSBPL8 and SYT1 genes. The fusion of the OSBPL8 and SYT1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OSBPL8-SYT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-RERE | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-REOR | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-REGO | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-REGR | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-REAQ | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-ORRE | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-OROR | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-ORGO | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-ORAQ | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-GORE | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-GOOR | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-GOGO | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-GOGR | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-GOAQ | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-GRRE | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-GROR | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-GRGO | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-GRGR | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-GRAQ | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-AQRE | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-AQOR | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-AQGO | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-AQGR | 20 (40 μL) | 200 μL |
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| OSBPL8-SYT1-20-AQAQ | 20 (40 μL) | 200 μL |
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SYT1 Gene Summary
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]
Gene Name: Synaptotagmin 1
Chromosome: CHR12: 79257772 -79845788
Locus: 12q21.2
OSBPL8 Gene Summary
This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Name: Oxysterol Binding Protein Like 8
Chromosome: CHR12: 76745577 -76953589
Locus: 12q21.2
Gene Diseases
The OSBPL8 SYT1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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