OSBPL2-CDH4 Fusion FISH Probe
The OSBPL2-CDH4 Fusion FISH Probe is used to confirm a fusion of the OSBPL2 and CDH4 genes. The fusion of the OSBPL2 and CDH4 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OSBPL2-CDH4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-RERE | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-REOR | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-REGO | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-REGR | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-REAQ | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-ORRE | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-OROR | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-ORGO | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-ORAQ | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-GORE | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-GOOR | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-GOGO | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-GOGR | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-GOAQ | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-GRRE | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-GROR | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-GRGO | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-GRGR | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-GRAQ | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-AQRE | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-AQOR | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-AQGO | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-AQGR | 20 (40 μL) | 200 μL |
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| OSBPL2-CDH4-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH4 Gene Summary
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Name: Cadherin 4
Chromosome: CHR20: 59827558 -60512299
Locus: 20q13.33
OSBPL2 Gene Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although the encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2014]
Gene Name: Oxysterol Binding Protein Like 2
Chromosome: CHR20: 60813579 -60871269
Locus: 20q13.33
Gene Diseases
The OSBPL2 CDH4 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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