OSBP2-MRPL43 Fusion FISH Probe
The OSBP2-MRPL43 Fusion FISH Probe is used to confirm a fusion of the OSBP2 and MRPL43 genes. The fusion of the OSBP2 and MRPL43 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OSBP2-MRPL43-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-RERE | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-REOR | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-REGO | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-REGR | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-REAQ | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-ORRE | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-OROR | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-ORGO | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-ORAQ | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-GORE | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-GOOR | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-GOGO | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-GOGR | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-GOAQ | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-GRRE | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-GROR | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-GRGO | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-GRGR | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-GRAQ | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-AQRE | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-AQOR | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-AQGO | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-AQGR | 20 (40 μL) | 200 μL |
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| OSBP2-MRPL43-20-AQAQ | 20 (40 μL) | 200 μL |
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OSBP2 Gene Summary
The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013]
Gene Name: Oxysterol Binding Protein 2
Chromosome: CHR22: 31090792 -31303811
Locus: 22q12.2
MRPL43 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene and the gene for a semaphorin class 4 protein (SEMA4G) overlap at map location 10q24.31 and are transcribed in opposite directions. Sequence analysis identified multiple transcript variants encoding at least four different protein isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein L43
Chromosome: CHR10: 102737578 -102747272
Locus: 10q24.31
Gene Diseases
The OSBP2 MRPL43 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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