OS9-ERBB3 Fusion FISH Probe
The OS9-ERBB3 Fusion FISH Probe is used to confirm a fusion of the OS9 and ERBB3 genes. The fusion of the OS9 and ERBB3 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OS9-ERBB3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-RERE | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-REOR | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-REGO | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-REGR | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-REAQ | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-ORRE | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-OROR | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-ORGO | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-ORAQ | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-GORE | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-GOOR | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-GOGO | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-GOGR | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-GOAQ | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-GRRE | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-GROR | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-GRGO | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-GRGR | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-GRAQ | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-AQRE | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-AQOR | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-AQGO | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-AQGR | 20 (40 μL) | 200 μL |
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| OS9-ERBB3-20-AQAQ | 20 (40 μL) | 200 μL |
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ERBB3 Gene Summary
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Erb-b2 Receptor Tyrosine Kinase 3
Chromosome: CHR12: 56473808 -56497291
Locus: 12q13.2
OS9 Gene Summary
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: OS9, Endoplasmic Reticulum Lectin
Chromosome: CHR12: 58087737 -58115340
Locus: 12q13.3-q14.1
Gene Diseases
The OS9 ERBB3 Fusion has been associated with the following diseases:
| Disease Name |
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| Thyroid Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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