ORAOV1-CCND1 Fusion FISH Probe
The ORAOV1-CCND1 Fusion FISH Probe is used to confirm a fusion of the ORAOV1 and CCND1 genes. The fusion of the ORAOV1 and CCND1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ORAOV1-CCND1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-RERE | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-REOR | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-REGO | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-REGR | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-REAQ | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-ORRE | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-OROR | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-ORGO | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-GORE | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-GOOR | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-GOGO | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-GOGR | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-GRRE | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-GROR | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-GRGO | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-GRGR | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-AQRE | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-AQOR | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-AQGO | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-AQGR | 20 (40 μL) | 200 μL |
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| ORAOV1-CCND1-20-AQAQ | 20 (40 μL) | 200 μL |
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CCND1 Gene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Name: Cyclin D1
Chromosome: CHR11: 69455872 -69469242
Locus: 11q13.3
ORAOV1 Gene Summary
The Oral Cancer Overexpressed 1 (ORAOV1) gene is located on chr11 :69480331-69490165 at 11q13.3.
Gene Name: Oral Cancer Overexpressed 1
Chromosome: CHR11: 69480331 -69490165
Locus: 11q13.3
Gene Diseases
The ORAOV1 CCND1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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