OPRL1-PRPF6 Fusion FISH Probe
The OPRL1-PRPF6 Fusion FISH Probe is used to confirm a fusion of the OPRL1 and PRPF6 genes. The fusion of the OPRL1 and PRPF6 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OPRL1-PRPF6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-RERE | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-REOR | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-REGO | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-REGR | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-REAQ | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-ORRE | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-OROR | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-ORGO | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-ORAQ | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-GORE | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-GOOR | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-GOGO | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-GOGR | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-GOAQ | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-GRRE | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-GROR | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-GRGO | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-GRGR | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-GRAQ | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-AQRE | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-AQOR | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-AQGO | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-AQGR | 20 (40 μL) | 200 μL |
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| OPRL1-PRPF6-20-AQAQ | 20 (40 μL) | 200 μL |
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OPRL1 Gene Summary
The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Gene Name: Opioid Related Nociceptin Receptor 1
Chromosome: CHR20: 62711470 -62731996
Locus: 20q13.33
PRPF6 Gene Summary
The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. [provided by RefSeq, Jul 2008]
Gene Name: Pre-mRNA Processing Factor 6
Chromosome: CHR20: 62612430 -62664453
Locus: 20q13.33
Gene Diseases
The OPRL1 PRPF6 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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