OPHN1-TNMD Fusion FISH Probe
The OPHN1-TNMD Fusion FISH Probe is used to confirm a fusion of the OPHN1 and TNMD genes. The fusion of the OPHN1 and TNMD genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OPHN1-TNMD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-RERE | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-REOR | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-REGO | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-REGR | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-REAQ | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-ORRE | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-OROR | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-ORGO | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-ORAQ | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-GORE | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-GOOR | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-GOGO | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-GOGR | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-GOAQ | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-GRRE | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-GROR | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-GRGO | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-GRGR | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-GRAQ | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-AQRE | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-AQOR | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-AQGO | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-AQGR | 20 (40 μL) | 200 μL |
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| OPHN1-TNMD-20-AQAQ | 20 (40 μL) | 200 μL |
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OPHN1 Gene Summary
This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked cognitive disability with cerebellar hypoplasia and distinctive facial dysmorhphism. [provided by RefSeq, Jul 2008]
Gene Name: Oligophrenin 1
Chromosome: CHRX: 67262185 -67653299
Locus: Xq12
TNMD Gene Summary
This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009]
Gene Name: Tenomodulin
Chromosome: CHRX: 99839789 -99854882
Locus: Xq22.1
Gene Diseases
The OPHN1 TNMD Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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