OPA1-PPP2R3A Fusion FISH Probe
The OPA1-PPP2R3A Fusion FISH Probe is used to confirm a fusion of the OPA1 and PPP2R3A genes. The fusion of the OPA1 and PPP2R3A genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OPA1-PPP2R3A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-RERE | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-REOR | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-REGO | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-REGR | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-REAQ | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-ORRE | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-OROR | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-ORGO | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-ORAQ | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-GORE | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-GOOR | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-GOGO | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-GOGR | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-GOAQ | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-GRRE | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-GROR | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-GRGO | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-GRGR | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-GRAQ | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-AQRE | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-AQOR | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-AQGO | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-AQGR | 20 (40 μL) | 200 μL |
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| OPA1-PPP2R3A-20-AQAQ | 20 (40 μL) | 200 μL |
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OPA1 Gene Summary
The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. [provided by RefSeq, Aug 2017]
Gene Name: OPA1, Mitochondrial Dynamin Like GTPase
Chromosome: CHR3: 193310932 -193415600
Locus: 3q29
PPP2R3A Gene Summary
This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
Gene Name: Protein Phosphatase 2 Regulatory Subunit B''alpha
Chromosome: CHR3: 135684514 -135866752
Locus: 3q22.2-q22.3
Gene Diseases
The OPA1 PPP2R3A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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