OPA1-EHHADH Fusion FISH Probe
The OPA1-EHHADH Fusion FISH Probe is used to confirm a fusion of the OPA1 and EHHADH genes. The fusion of the OPA1 and EHHADH genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OPA1-EHHADH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-RERE | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-REOR | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-REGO | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-REGR | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-REAQ | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-ORRE | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-OROR | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-ORGO | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-ORAQ | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-GORE | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-GOOR | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-GOGO | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-GOGR | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-GOAQ | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-GRRE | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-GROR | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-GRGO | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-GRGR | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-GRAQ | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-AQRE | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-AQOR | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-AQGO | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-AQGR | 20 (40 μL) | 200 μL |
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| OPA1-EHHADH-20-AQAQ | 20 (40 μL) | 200 μL |
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EHHADH Gene Summary
The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Name: Enoyl-CoA Hydratase And 3-hydroxyacyl CoA Dehydrogenase
Chromosome: CHR3: 184908411 -184971886
Locus: 3q27.2
OPA1 Gene Summary
The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. [provided by RefSeq, Aug 2017]
Gene Name: OPA1, Mitochondrial Dynamin Like GTPase
Chromosome: CHR3: 193310932 -193415600
Locus: 3q29
Gene Diseases
The OPA1 EHHADH Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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