OLFM2-PSENEN Fusion FISH Probe
The OLFM2-PSENEN Fusion FISH Probe is used to confirm a fusion of the OLFM2 and PSENEN genes. The fusion of the OLFM2 and PSENEN genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OLFM2-PSENEN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-RERE | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-REOR | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-REGO | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-REGR | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-REAQ | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-ORRE | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-OROR | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-ORGO | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-ORAQ | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-GORE | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-GOOR | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-GOGO | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-GOGR | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-GOAQ | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-GRRE | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-GROR | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-GRGO | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-GRGR | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-GRAQ | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-AQRE | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-AQOR | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-AQGO | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-AQGR | 20 (40 μL) | 200 μL |
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| OLFM2-PSENEN-20-AQAQ | 20 (40 μL) | 200 μL |
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PSENEN Gene Summary
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: Presenilin Enhancer Gamma-secretase Subunit
Chromosome: CHR19: 36236493 -36237903
Locus: 19q13.12
OLFM2 Gene Summary
The Olfactomedin 2 (OLFM2) gene is located on chr19 :9964393-10047070 at 19p13.2.
Gene Name: Olfactomedin 2
Chromosome: CHR19: 9964393 -10047070
Locus: 19p13.2
Gene Diseases
The OLFM2 PSENEN Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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