OCA2-HERC2 Fusion FISH Probe
The OCA2-HERC2 Fusion FISH Probe is used to confirm a fusion of the OCA2 and HERC2 genes. The fusion of the OCA2 and HERC2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OCA2-HERC2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-RERE | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-REOR | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-REGO | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-REGR | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-REAQ | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-ORRE | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-OROR | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-ORGO | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-ORAQ | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-GORE | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-GOOR | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-GOGO | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-GOGR | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-GOAQ | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-GRRE | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-GROR | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-GRGO | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-GRGR | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-GRAQ | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-AQRE | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-AQOR | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-AQGO | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-AQGR | 20 (40 μL) | 200 μL |
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| OCA2-HERC2-20-AQAQ | 20 (40 μL) | 200 μL |
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OCA2 Gene Summary
This gene encodes the human homolog of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine, which is a precursor to melanin synthesis. It is involved in mammalian pigmentation, where it may control skin color variation and act as a determinant of brown or blue eye color. Mutations in this gene result in type 2 oculocutaneous albinism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: OCA2 Melanosomal Transmembrane Protein
Chromosome: CHR15: 28000022 -28344458
Locus: 15q12-q13.1
HERC2 Gene Summary
This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]
Gene Name: HECT And RLD Domain Containing E3 Ubiquitin Protein Ligase 2
Chromosome: CHR15: 28356187 -28567295
Locus: 15q13.1
Gene Diseases
The OCA2 HERC2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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