OBSCN-DISC1 Fusion FISH Probe
The OBSCN-DISC1 Fusion FISH Probe is used to confirm a fusion of the OBSCN and DISC1 genes. The fusion of the OBSCN and DISC1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OBSCN-DISC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-RERE | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-REOR | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-REGO | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-REGR | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-REAQ | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-ORRE | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-OROR | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-ORGO | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-GORE | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-GOOR | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-GOGO | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-GOGR | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-GRRE | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-GROR | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-GRGO | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-GRGR | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-AQRE | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-AQOR | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-AQGO | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-AQGR | 20 (40 μL) | 200 μL |
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| OBSCN-DISC1-20-AQAQ | 20 (40 μL) | 200 μL |
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DISC1 Gene Summary
This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1;11)(q42.1;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Disrupted In Schizophrenia 1
Chromosome: CHR1: 231762560 -232177019
Locus: 1q42.2
OBSCN Gene Summary
The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Obscurin, Cytoskeletal Calmodulin And Titin-interacting RhoGEF
Chromosome: CHR1: 228395860 -228566575
Locus: 1q42.13
Gene Diseases
The OBSCN DISC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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