OBSCN-CASZ1 Fusion FISH Probe
The OBSCN-CASZ1 Fusion FISH Probe is used to confirm a fusion of the OBSCN and CASZ1 genes. The fusion of the OBSCN and CASZ1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OBSCN-CASZ1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-RERE | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-REOR | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-REGO | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-REGR | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-REAQ | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-ORRE | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-OROR | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-ORGO | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-ORAQ | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-GORE | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-GOOR | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-GOGO | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-GOGR | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-GOAQ | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-GRRE | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-GROR | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-GRGO | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-GRGR | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-GRAQ | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-AQRE | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-AQOR | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-AQGO | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-AQGR | 20 (40 μL) | 200 μL |
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| OBSCN-CASZ1-20-AQAQ | 20 (40 μL) | 200 μL |
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CASZ1 Gene Summary
The protein encoded by this gene is a zinc finger transcription factor. The encoded protein may function as a tumor suppressor, and single nucleotide polymorphisms in this gene are associated with blood pressure variation. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Gene Name: Castor Zinc Finger 1
Chromosome: CHR1: 10696665 -10856707
Locus: 1p36.22
OBSCN Gene Summary
The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Obscurin, Cytoskeletal Calmodulin And Titin-interacting RhoGEF
Chromosome: CHR1: 228395860 -228566575
Locus: 1q42.13
Gene Diseases
The OBSCN CASZ1 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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