OAZ2-RBPMS2 Fusion FISH Probe
The OAZ2-RBPMS2 Fusion FISH Probe is used to confirm a fusion of the OAZ2 and RBPMS2 genes. The fusion of the OAZ2 and RBPMS2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OAZ2-RBPMS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-RERE | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-REOR | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-REGO | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-REGR | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-REAQ | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-ORRE | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-OROR | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-ORGO | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-GORE | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-GOOR | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-GOGO | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-GOGR | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-GRRE | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-GROR | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-GRGO | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-GRGR | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-AQRE | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-AQOR | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-AQGO | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-AQGR | 20 (40 μL) | 200 μL |
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| OAZ2-RBPMS2-20-AQAQ | 20 (40 μL) | 200 μL |
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OAZ2 Gene Summary
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
Gene Name: Ornithine Decarboxylase Antizyme 2
Chromosome: CHR15: 64979772 -64995462
Locus: 15q22.31
RBPMS2 Gene Summary
The protein encoded by this gene is a member of the RNA recognition motif (RRM)-containing protein family and is involved in the development and dedifferentiation of digestive smooth muscle cells. The encoded protein functions as a homodimer and indirectly inhibits the bone morphogenetic protein pathway. [provided by RefSeq, Aug 2016]
Gene Name: RNA Binding Protein With Multiple Splicing 2
Chromosome: CHR15: 65032094 -65067770
Locus: 15q22.31
Gene Diseases
The OAZ2 RBPMS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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