OAZ1-YBX2 Fusion FISH Probe
The OAZ1-YBX2 Fusion FISH Probe is used to confirm a fusion of the OAZ1 and YBX2 genes. The fusion of the OAZ1 and YBX2 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| OAZ1-YBX2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-RERE | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-REOR | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-REGO | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-REGR | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-OROR | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-GORE | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-GROR | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| OAZ1-YBX2-20-AQAQ | 20 (40 μL) | 200 μL |
|
OAZ1 Gene Summary
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
Gene Name: Ornithine Decarboxylase Antizyme 1
Chromosome: CHR19: 2269519 -2273487
Locus: 19p13.3
YBX2 Gene Summary
This gene encodes a nucleic acid binding protein which is highly expressed in germ cells. The encoded protein binds to a Y-box element in the promoters of certain genes but also binds to mRNA transcribed from these genes. Pseudogenes for this gene are located on chromosome 10 and 15. [provided by RefSeq, Feb 2012]
Gene Name: Y-box Binding Protein 2
Chromosome: CHR17: 7191570 -7197876
Locus: 17p13.1
Gene Diseases
The OAZ1 YBX2 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|