NXT1-VPS16 Fusion FISH Probe
The NXT1-VPS16 Fusion FISH Probe is used to confirm a fusion of the NXT1 and VPS16 genes. The fusion of the NXT1 and VPS16 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NXT1-VPS16-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-RERE | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-REOR | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-REGO | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-REGR | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-REAQ | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-ORRE | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-OROR | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-ORGO | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-ORAQ | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-GORE | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-GOOR | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-GOGO | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-GOGR | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-GOAQ | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-GRRE | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-GROR | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-GRGO | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-GRGR | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-GRAQ | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-AQRE | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-AQOR | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-AQGO | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-AQGR | 20 (40 μL) | 200 μL |
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| NXT1-VPS16-20-AQAQ | 20 (40 μL) | 200 μL |
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NXT1 Gene Summary
The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Transport Factor 2 Like Export Factor 1
Chromosome: CHR20: 23331372 -23335408
Locus: 20p11.21
VPS16 Gene Summary
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps16 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]
Gene Name: VPS16, CORVET/HOPS Core Subunit
Chromosome: CHR20: 2821372 -2847378
Locus: 20p13
Gene Diseases
The NXT1 VPS16 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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