NXN-ABR Fusion FISH Probe
The NXN-ABR Fusion FISH Probe is used to confirm a fusion of the NXN and ABR genes. The fusion of the NXN and ABR genes has been associated with Lung Adenocarcinoma, Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma, and Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NXN-ABR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-RERE | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-REOR | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-REGO | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-REGR | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-REAQ | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-ORRE | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-OROR | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-ORGO | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-ORAQ | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-GORE | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-GOOR | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-GOGO | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-GOGR | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-GOAQ | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-GRRE | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-GROR | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-GRGO | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-GRGR | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-GRAQ | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-AQRE | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-AQOR | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-AQGO | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-AQGR | 20 (40 μL) | 200 μL |
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| NXN-ABR-20-AQAQ | 20 (40 μL) | 200 μL |
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ABR Gene Summary
This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]
Gene Name: Active BCR-related
Chromosome: CHR17: 906758 -1090616
Locus: 17p13.3
NXN Gene Summary
This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015]
Gene Name: Nucleoredoxin
Chromosome: CHR17: 702552 -882998
Locus: 17p13.3
Gene Diseases
The NXN ABR Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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