NXF1-WDR74 Fusion FISH Probe
The NXF1-WDR74 Fusion FISH Probe is used to confirm a fusion of the NXF1 and WDR74 genes. The fusion of the NXF1 and WDR74 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NXF1-WDR74-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-RERE | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-REOR | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-REGO | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-REGR | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-REAQ | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-ORRE | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-OROR | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-ORGO | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-ORAQ | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-GORE | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-GOOR | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-GOGO | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-GOGR | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-GOAQ | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-GRRE | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-GROR | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-GRGO | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-GRGR | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-GRAQ | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-AQRE | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-AQOR | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-AQGO | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-AQGR | 20 (40 μL) | 200 μL |
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| NXF1-WDR74-20-AQAQ | 20 (40 μL) | 200 μL |
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NXF1 Gene Summary
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear RNA Export Factor 1
Chromosome: CHR11: 62559597 -62572964
Locus: 11q12.3
WDR74 Gene Summary
The WD Repeat Domain 74 (WDR74) gene is located on chr11 :62600382-62607628 at 11q12.3.
Gene Name: WD Repeat Domain 74
Chromosome: CHR11: 62600382 -62607628
Locus: 11q12.3
Gene Diseases
The NXF1 WDR74 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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