NUP98-TMEM117 Fusion FISH Probe
The NUP98-TMEM117 Fusion FISH Probe is used to confirm a fusion of the NUP98 and TMEM117 genes. The fusion of the NUP98 and TMEM117 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUP98-TMEM117-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-RERE | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-REOR | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-REGO | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-REGR | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-REAQ | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-ORRE | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-OROR | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-ORGO | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-GORE | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-GOOR | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-GOGO | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-GOGR | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-GRRE | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-GROR | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-GRGO | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-GRGR | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-AQRE | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-AQOR | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-AQGO | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-AQGR | 20 (40 μL) | 200 μL |
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| NUP98-TMEM117-20-AQAQ | 20 (40 μL) | 200 μL |
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NUP98 Gene Summary
Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]
Gene Name: Nucleoporin 98
Chromosome: CHR11: 3696239 -3819022
Locus: 11p15.4
TMEM117 Gene Summary
The Transmembrane Protein 117 (TMEM117) gene is located on chr12 :44229961-44783541 at 12q12.
Gene Name: Transmembrane Protein 117
Chromosome: CHR12: 44229961 -44783541
Locus: 12q12
Gene Diseases
The NUP98 TMEM117 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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