NUP98-MLXIP Fusion FISH Probe
The NUP98-MLXIP Fusion FISH Probe is used to confirm a fusion of the NUP98 and MLXIP genes. The fusion of the NUP98 and MLXIP genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUP98-MLXIP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-RERE | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-REOR | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-REGO | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-REGR | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-REAQ | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-ORRE | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-OROR | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-ORGO | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-GORE | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-GOOR | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-GOGO | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-GOGR | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-GRRE | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-GROR | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-GRGO | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-GRGR | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-AQRE | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-AQOR | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-AQGO | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-AQGR | 20 (40 μL) | 200 μL |
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| NUP98-MLXIP-20-AQAQ | 20 (40 μL) | 200 μL |
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NUP98 Gene Summary
Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]
Gene Name: Nucleoporin 98
Chromosome: CHR11: 3696239 -3819022
Locus: 11p15.4
MLXIP Gene Summary
This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014]
Gene Name: MLX Interacting Protein
Chromosome: CHR12: 122516759 -122628967
Locus: 12q24.31
Gene Diseases
The NUP98 MLXIP Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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