NUP88-NLRP1 Fusion FISH Probe
The NUP88-NLRP1 Fusion FISH Probe is used to confirm a fusion of the NUP88 and NLRP1 genes. The fusion of the NUP88 and NLRP1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUP88-NLRP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-RERE | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-REOR | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-REGO | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-REGR | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-REAQ | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-ORRE | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-OROR | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-ORGO | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-GORE | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-GOOR | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-GOGO | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-GOGR | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-GRRE | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-GROR | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-GRGO | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-GRGR | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-AQRE | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-AQOR | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-AQGO | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-AQGR | 20 (40 μL) | 200 μL |
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| NUP88-NLRP1-20-AQAQ | 20 (40 μL) | 200 μL |
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NUP88 Gene Summary
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Gene Name: Nucleoporin 88
Chromosome: CHR17: 5289345 -5323059
Locus: 17p13.2
NLRP1 Gene Summary
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Name: NLR Family Pyrin Domain Containing 1
Chromosome: CHR17: 5404718 -5487832
Locus: 17p13.2
Gene Diseases
The NUP88 NLRP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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