NUP188-SPTAN1 Fusion FISH Probe
The NUP188-SPTAN1 Fusion FISH Probe is used to confirm a fusion of the NUP188 and SPTAN1 genes. The fusion of the NUP188 and SPTAN1 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUP188-SPTAN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-RERE | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-REOR | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-REGO | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-REGR | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-REAQ | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-ORRE | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-OROR | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-ORGO | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-GORE | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-GOOR | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-GOGO | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-GOGR | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-GRRE | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-GROR | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-GRGO | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-GRGR | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-AQRE | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-AQOR | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-AQGO | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-AQGR | 20 (40 μL) | 200 μL |
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| NUP188-SPTAN1-20-AQAQ | 20 (40 μL) | 200 μL |
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SPTAN1 Gene Summary
Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
Gene Name: Spectrin Alpha, Non-erythrocytic 1
Chromosome: CHR9: 131314836 -131395944
Locus: 9q34.11
NUP188 Gene Summary
The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013]
Gene Name: Nucleoporin 188
Chromosome: CHR9: 131709976 -131769374
Locus: 9q34.11
Gene Diseases
The NUP188 SPTAN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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