NUP153-MAK Fusion FISH Probe
The NUP153-MAK Fusion FISH Probe is used to confirm a fusion of the NUP153 and MAK genes. The fusion of the NUP153 and MAK genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUP153-MAK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-RERE | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-REOR | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-REGO | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-REGR | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-REAQ | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-ORRE | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-OROR | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-ORGO | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-GORE | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-GOOR | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-GOGO | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-GOGR | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-GRRE | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-GROR | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-GRGO | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-GRGR | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-AQRE | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-AQOR | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-AQGO | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-AQGR | 20 (40 μL) | 200 μL |
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| NUP153-MAK-20-AQAQ | 20 (40 μL) | 200 μL |
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MAK Gene Summary
The product of this gene is a serine/threonine protein kinase related to kinases involved in cell cycle regulation. Studies of the mouse and rat homologs have localized the kinase to the chromosomes during meiosis in spermatogenesis, specifically to the synaptonemal complex that exists while homologous chromosomes are paired. Mutations in this gene have been associated with ciliary defects resulting in retinitis pigmentosa 62. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Gene Name: Male Germ Cell Associated Kinase
Chromosome: CHR6: 10762955 -10838788
Locus: 6p24.2
NUP153 Gene Summary
Nuclear pore complexes regulate the transport of macromolecules between the nucleus and cytoplasm. They are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. Nucleoporins are glycoproteins found in nuclear pores and contain characteristic pentapeptide XFXFG repeats as well as O-linked N-acetylglucosamine residues oriented towards the cytoplasm. The protein encoded by this gene has three distinct domains: a N-terminal region containing a pore targeting and an RNA-binding domain domain, a central region containing multiple zinc finger motifs, and a C-terminal region containing multiple XFXFG repeats. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Gene Name: Nucleoporin 153
Chromosome: CHR6: 17615268 -17706818
Locus: 6p22.3
Gene Diseases
The NUP153 MAK Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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