NUMB-TSHR Fusion FISH Probe
The NUMB-TSHR Fusion FISH Probe is used to confirm a fusion of the NUMB and TSHR genes. The fusion of the NUMB and TSHR genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUMB-TSHR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-RERE | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-REOR | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-REGO | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-REGR | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-REAQ | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-ORRE | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-OROR | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-ORGO | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-GORE | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-GOOR | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-GOGO | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-GOGR | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-GRRE | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-GROR | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-GRGO | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-GRGR | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-AQRE | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-AQOR | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-AQGO | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-AQGR | 20 (40 μL) | 200 μL |
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| NUMB-TSHR-20-AQAQ | 20 (40 μL) | 200 μL |
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TSHR Gene Summary
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Gene Name: Thyroid Stimulating Hormone Receptor
Chromosome: CHR14: 81421868 -81612646
Locus: 14q31.1
NUMB Gene Summary
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Name: NUMB, Endocytic Adaptor Protein
Chromosome: CHR14: 73741917 -73925286
Locus: 14q24.2-q24.3
Gene Diseases
The NUMB TSHR Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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