NUMB-HEATR4 Fusion FISH Probe
The NUMB-HEATR4 Fusion FISH Probe is used to confirm a fusion of the NUMB and HEATR4 genes. The fusion of the NUMB and HEATR4 genes has been associated with Uterine Corpus Endometrial Carcinoma, and Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NUMB-HEATR4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-RERE | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-REOR | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-REGO | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-REGR | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-REAQ | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-ORRE | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-OROR | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-ORGO | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-ORAQ | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-GORE | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-GOOR | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-GOGO | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-GOGR | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-GOAQ | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-GRRE | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-GROR | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-GRGO | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-GRGR | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-GRAQ | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-AQRE | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-AQOR | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-AQGO | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-AQGR | 20 (40 μL) | 200 μL |
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| NUMB-HEATR4-20-AQAQ | 20 (40 μL) | 200 μL |
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NUMB Gene Summary
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Name: NUMB, Endocytic Adaptor Protein
Chromosome: CHR14: 73741917 -73925286
Locus: 14q24.2-q24.3
HEATR4 Gene Summary
The HEAT Repeat Containing 4 (HEATR4) gene is located on chr14 :73945188-74025651 at 14q24.3.
Gene Name: HEAT Repeat Containing 4
Chromosome: CHR14: 73945188 -74025651
Locus: 14q24.3
Gene Diseases
The NUMB HEATR4 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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